Translational Surgery

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 1  |  Issue : 3  |  Page : 69--74

High expression of mir-25 predicting poor prognosis in gastric cancer


Chuanli Ren1, Wenshu Wang2, Chongxu Han3, Hui Chen4, Deyuan Fu5, Daxin Wang3, Ming Shen2 
1 Department of Clinical Medical Laboratory, Clinical Medical Testing Laboratory, Northern Jiangsu People's Hospital and Clinical Medical College of Yangzhou University, Yangzhou; Department of Epidemiology and Biostatistics, Ministry of Education, Key Laboratory of Modern Toxicology, School of Public Health, Nanjing Medical University, Nanjing, China
2 Department of Chemistry, College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, China
3 Department of Clinical Medical Laboratory, Clinical Medical Testing Laboratory, Northern Jiangsu People's Hospital and Clinical Medical College of Yangzhou University, Yangzhou, China
4 Division of Geriatric Medicine, Northern Jiangsu People's Hospital and Clinical Medical College of Yangzhou University, Yangzhou, China
5 Department of Breast Oncology Surgery, Northern Jiangsu People's Hospital and Clinical Medical College of Yangzhou University, Yangzhou, China

Correspondence Address:
Chongxu Han
Clinical Medical Testing Laboratory, Northern Jiangsu People«SQ»s Hospital and Clinical Medical College of Yangzhou University, No. 98 Western Nantong Road, Yangzhou 225001
China

Aim: The aim of this study was to explore miR-25 expression pattern and its prognostic value in gastric carcinoma (GC). Methods: MiR-25 expression was detected using miRNA-locked nucleic acid in situ hybridization in 180 patients with GC undergoing surgery. Correlation with clinicopathological features and overall survival (OS) was analyzed. Results: MiR-25 expression was decreased in 10.0% (18/180) of GC, increased in 62.2% (112/180), and unchanged in 27.8% (50/180), compared to samples of morphologically normal tissue taken from the same patient (P < 0.001). Univariate analysis showed that high miR-25 expression, tumor stage, tumor status, node status, and tumor size were significant negative prognostic predictors for OS in patients with GC, and the results were shown as P < 0.001, P < 0.001, P = 0.002, P> 0.001, and P = 0.001, respectively. High miR-25 expression remained a significant predictor of shorter survival in stage II (n = 56, P = 0.015) and stage III (n = 92, P < 0.001) GC. Multivariate regression analysis demonstrated that tumor status (hazard ratio [HR]: 1.91; 95% confidence interval [CI]: 0.79-4.62; P = 0.151), stage (HR: 2.26; 95% CI: 1.30-3.94; P = 0.004), lymph node metastasis (HR: 1.40; 95% CI: 0.73-2.68; P = 0.309), high expression of miR-25 (HR: 2.39; 95% CI: 1.53-3.72; P < 0.001), and tumor size (HR: 2.29; 95% CI: 1.40-3.74; P = 0.001) predicted shorter OS. Conclusion: High expression of miR-25 was associated with decreased OS. Thus, miR-25 may be useful for prognosis evaluation and may provide a novel treatment target in patients with GC.


How to cite this article:
Ren C, Wang W, Han C, Chen H, Fu D, Wang D, Shen M. High expression of mir-25 predicting poor prognosis in gastric cancer.Transl Surg 2016;1:69-74


How to cite this URL:
Ren C, Wang W, Han C, Chen H, Fu D, Wang D, Shen M. High expression of mir-25 predicting poor prognosis in gastric cancer. Transl Surg [serial online] 2016 [cited 2021 Sep 26 ];1:69-74
Available from: http://www.translsurg.com/article.asp?issn=2468-5585;year=2016;volume=1;issue=3;spage=69;epage=74;aulast=Ren;type=0