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   Table of Contents - Current issue
Coverpage
January-March 2019
Volume 4 | Issue 1
Page Nos. 1-16

Online since Wednesday, May 8, 2019

Accessed 816 times.

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EDITORIAL  

Intraoperative surgical pathology examination and translational medicine p. 1
Viroj Wiwanitkit
DOI:10.4103/ts.ts_18_18  
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ORIGINAL ARTICLE Top

Ankle–Brachial Index, plasma homocysteine, and brachial-ankle pulse wave velocity are important indicators in the diagnosis of early stage lower-extremity arterial occlusive disease p. 2
Tan Li, Yang Zhang, Wangde Zhang
DOI:10.4103/ts.ts_6_19  
Background: This study evaluated noninvasive methods for the diagnosis and classification of lower-extremity arterial occlusive disease (LEAOD), specifically, plasma homocysteine (pHcy), ankle–brachial index (ABI), and brachial-ankle pulse wave velocity (baPWV). Materials and Methods: The study involved 102 patients with intermittent claudication treated at Beijing Chao Yang Hospital from 2010 to 2011. The affected arteries were assessed by computed tomography angiography (CTA) and categorized depending on the degree of occlusion as normal, stenotic, or occluded. ABI, pHcy, and baPWV were measured and compared among the groups. Factors that can affect ABI readings were analyzed. Results: Compared with patients in the normal group, the stenotic and occluded patients had significantly higher pHcy and baPWV, and lower ABI levels. The pHcy levels of the stenotic and occluded groups were similar. While statistically significant different ABI and baPWV levels were shown between the stenotic and occluded groups. The t values were 9.43 and 3.76, and the P < 0.001 and 0.001, respectively. Hypertension, diabetes mellitus, and blood cholesterol, C-reaction protein, and pHcy levels can influence the ABI value. Conclusion: ABI, pHcy, and baPWV values correlated with the results of the CTA examination with regard to LEAOD classification. ABI and baPWV may be useful for the categorical diagnosis of the disease. These findings contribute to the early diagnosis of LEAOD using noninvasive methods.
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REVIEW ARTICLES Top

Application of single-cell sequencing technology in the study of cardiovascular development and diseases p. 7
Chuxiang Lei, Siliang Chen, Yuehong Zheng
DOI:10.4103/ts.ts_2_19  
Single-cell sequencing technology has developed rapidly in recent years and has demonstrated its power in many fields, especially in the field of tumor-, immunity-, and stem cell-related researches, where it explains many biological laws that remained uncovered. In terms of cardiovascular disease, in spite of application in studies of atherosclerotic plaque and explaining the cellular heterogeneity in plaque formation, single-cell sequencing technology is relatively limited and is in its infancy. This article reviews the application of single-cell sequencing technology in cardiovascular field in recent years and makes a brief comparison with its application in other fields, hoping to point out the way for future research.
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Surgical Treatment for perianal Crohn's disease p. 13
Dan Gan, Wei Jin, Ying Li, Chang-Peng Han, Zhen-Yi Wang
DOI:10.4103/ts.ts_19_18  
Crohn's disease (CD) is an inflammatory disease that occurs in unexplained gastrointestinal mucosa. Anal fistula is a common complication of CD. Anal fistula accounts for 15% of patients with ileocolonic CD, and 92% of CD patients with colon and rectum involvement have anal fistula. Although perianal CD is an anorectal benign disease, it significantly affects the patients' quality of life. Medical and surgical management are two major treatment approaches for Crohn's anal fistula. Drug treatment includes antibiotics, immunological agents, and biological agents. Nearly 30% of patients with CD anal fistula can be cured by standard medical treatment, and 70% need surgical intervention. The purpose of the current surgical treatment is to alleviate local symptoms and protect the anal sphincter function. The surgical treatment of Crohn's anal fistula depends largely on the type of anal fistula, the relationship with the sphincter, and whether it is in the remission of CD.
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