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   Table of Contents - Current issue
January-March 2018
Volume 3 | Issue 1
Page Nos. 1-22

Online since Thursday, March 22, 2018

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A modified uncut roux-en-y anastomosis in laparoscopic-assisted distal gastrectomy: Balance of the cost and minimally invasion p. 1
Shun Zhang, Tao Du, Dongyi Yan, Xiaohua Jiang, Chun Song
Aim: The aim of the study was to evaluate the cost of minimally invasive surgery using a modified uncut Roux-en-Y anastomosis technique in laparoscopic distal radical gastrectomy patients with gastric cancer. Methods: Clinical and cost data were reviewed on the perioperative outcomes of 15 gastric cancer patients who received laparoscopic distal radical gastrectomy using uncut Roux-en-Y anastomosis from January 2016 to December 2016 in the Department of Gastrointestinal Surgery, Shanghai East Hospital. Results: The mean operation time was 175 ± 30 min. Mean hospitalization expense was 9829 USD and mean linear stapler expense was 2940 USD. Laparoscopic distal radical gastrectomy with uncut Roux-en-Y anastomosis was successfully carried out in all the patients. There were no serious complications and no death in this series. Conclusion: Modified uncut Roux-en-Y anastomosis in laparoscopic distal radical gastrectomy may be a good way to balance the cost and minimally invasive surgery.
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MicroRNA-564 promotes the differentiation and proliferation of synovial mesenchymal stem cells into chondrocytes by targeting transforming growth factor beta 1 p. 6
Xiangyi Sun, Pin Zhang, Lei Zhang, Jianning Zhao, Liwu Zhou
Aim: To investigate the role of miR-564 in promoting the proliferation and differentiation of synovial mesenchymal stem cells (SMSCs) to chondrocytes. Methods: Third-generation SMSCs were used, and the experiments involved untreated SMSCs (control; Group A), SMSCs transfected with Hsa-miR-564 inhibitor NC (inhibitor blank; Group B), and SMSCs transfected with Hsa-miR-564 inhibitor (Group C). The expression of miR-564 in SMSCs was determined by real-time quantitative polymerase chain reaction. The SMSCs were induced to form cartilage for 3 weeks. The morphology of the induced chondrocytes was observed by hematoxylin and eosin and toluidine blue staining and cell viability recorded. Chondrocyte differentiation of SMSCs related to genes and proteins (COL2A1, Aggrecan, SOX9, transforming growth factor beta 1 [TGF-β1], and Smad4) was assessed. The chondrogenic effect of miR-564 was examined after blocking the target gene TGF-β1. Results: The morphology and characteristics of the induced cells were consistent with those of chondrocytes. The cell proliferative rate of Group C (miR-564 downregulation) was significantly higher than that of other groups. The expression of genes and proteins related to chondrocyte differentiation was significantly decreased in Group C. The relative expression of genes related to cartilage differentiation decreased after blocking TGF-β1. Conclusion: The downregulation mediated by miR-564 can promote the differentiation and proliferation of SMSCs into chondrocytes by targeting TGF-β1.
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Medical applications of polyether ether ketone p. 12
Yitong Guo, Shenggui Chen, Jing Wang, Bingheng Lu
Polyether ether ketone (PEEK) has been widely used during the past decades in the medical field. Its versatile nature makes PEEK very popular in a variety of medical devices. The purpose of this article is to summarize the medical applications of PEEK in following fields: cranioplasty, dental implants, interbody fusion, joint replacements, soft-tissue repairs, and cardiac surgery. PEEK, as a biocompatible polymer, has been used in fields related to tissue fixation and reconstruction. This is largely due to its superior mechanical characteristics and biocompatibility. The author believes that as collaboration between medical professionals and engineers becomes more standard, PEEK and its composites will become more available and versatile.
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Radiobasilic fistula: An efficient and still underused autogenous hemodialysis vascular access p. 17
Abdullah Al Wahbi
Radiobasilic fistula (RBF) is underutilized and not considered as the second option after radiocephalic fistula (RCF). We present a case study of a 45-year-old male patient with a medical history of diabetes mellitus and chronic renal insufficiency who presented at our vascular clinic for predialysis creation of hemodialysis vascular access. RBF was performed due to the patient's young age, the high possibility of long-term hemodialysis, and the small diameter of the forearm cephalic vein (1.5 mm). Most of the guidelines recommend brachiocephalic fistula (BCF) or brachiobasilic fistula (BBF) as the second choice following RCF, despite the reported efficiency of RBF. This case supports the previous studies recommending the inclusion of RBF as the second choice for vascular access in international guidelines, in addition to BCF, BBF, and over arteriovenous grafts.
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Differentiation of esophageal duplication cysts from esophageal bronchogenic cysts: A case report and literature review p. 20
Jun Yang, Tao Zhou, Jiaqiang Fu, Yimei Zhang
Esophageal bronchogenic cysts located in inferior esophagus are rare. Here, we report on the case of a 12-year-old female patient who presented at our institution with dyspepsia and abdominal distention for 2 years with no other symptoms. Physical examination of abdomen and chest was negative, and laboratory tests did not show any abnormal results. However, computed tomography imaging showed a mass of about 8 cm × 8 cm × 4 cm in the lower esophagus compressing the stomach. The preoperative diagnosis was determined to be an inferior esophageal duplication cyst. A transabdominal excision of the cyst was performed 5 days after hospital admission. Pathology revealed an esophageal bronchogenic cyst. The case report and literature shows that differences exist between esophageal duplication cysts and esophageal bronchogenic cysts.
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