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   Table of Contents - Current issue
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October-December 2018
Volume 3 | Issue 4
Page Nos. 69-87

Online since Wednesday, December 26, 2018

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ORIGINAL ARTICLES  

Rapid increase in serum iron level after oral iron intake as an indicator of duodenal iron absorption and inverse regulation of iron absorption by hepcidin expression p. 69
Xipeng Wang, Bing Yuan, Mitsuteru Yokoyama, Ping Liu
DOI:10.4103/ts.ts_15_18  
Aim: Hepcidin is a hepatocyte-derived peptide that is thought to be involved in the regulation of intestinal iron absorption. Ferric citrate (FC) is a phosphate binder with additional effects on iron absorption. Better understanding of iron absorption under various levels of hepcidin may improve FC supplementation in individuals with renal anemia. We provide a new method to predict the individual iron absorption ability of the duodenum. Methods: Rats on an ordinary diet were given 10 mg of FC, and the serum concentrations of hepcidin and iron were monitored for 24 h. Rats with hepcidin levels induced by using alternative methods such as bloodletting or intravenous iron loading were also given FC, and serum iron level was measured at 2 h after oral iron intake (2-h oral iron absorption test). Results: Serum iron level increased constantly within 2 h after oral iron intake, and serum hepcidin level peaked 4 h after the iron level peaked. In the oral iron absorption test, the hepcidin levels inversely correlated with increased serum iron levels and hepcidin expression levels of >80 ng/mL completely inhibited the increase in iron absorption. Conclusion: This study suggests that hepcidin expression may be a strong mediator to regulate iron absorption and that performing an oral iron absorption test with hepcidin may help improve oral iron dosing schedules in patients undergoing hemodialysis.
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Investigating the efficacy of electroacupuncture and hyperbaric oxygen therapies on the awakening of coma patients with severe brain trauma p. 75
Xuejian Wang, Yang Chen, Zhifeng Wang
DOI:10.4103/ts.ts_14_18  
Aim: To investigate the effect of electroacupuncture and hyperbaric oxygen therapies on the awakening of coma patients with severe brain trauma. Methods: One hundred and twenty severe brain injury patients were enrolled and randomly divided into four groups: conventional treatment group, electroacupuncture treatment group, adjuvant hyperbaric oxygen treatment group, and adjuvant electroacupuncture plus hyperbaric oxygen treatment group, with 30 patients in each group. The changes in Glasgow Coma Scale (GCS) and Glasgow Outcome Scale were recorded posttreatment. Results: Posttreatment, the GCS of all the four groups was increased. The GCSs of electroacupuncture treatment group, hyperbaric oxygen treatment group, and electroacupuncture plus hyperbaric oxygen treatment group were significantly higher than control group (P < 0.05). There was no significant difference in GCSs between electroacupuncture group and hyperbaric oxygen group (P > 0.05). Further, combining electroacupuncture and hyperbaric oxygen treatment made no significant improvement in GCS over individual treatments (P > 0.05). Conclusion: In addition to conventional treatment, the use of electroacupuncture and hyperbaric oxygen therapies may have a beneficial effect on patients' nervous system and thus aid in the awakening of coma patients.
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The efficacy of double-tube polycaprolactone/β-tricalcium phosphate bioceramic composite in the treatment of bone defects p. 79
Genwei Guo, Gentao Fan, Xiaozhou Liu, Xin Shi, Guangxin Zhou, Xing Zhou
DOI:10.4103/ts.ts_16_18  
Aim: The study aims to investigate the efficacy of double-tube polycaprolactone (PCL)/β-tricalcium phosphate (β-TCP) bioceramic composites in the treatment of bone defects. Methods: Forty healthy female New Zealand white rabbits, aged 6–10 months and weighing about 3 kg, were randomly divided into observation group (n = 20) and control group (n = 20) according to the random number table. The animals in the observation group were implanted with double-tube PCL/β-TCP bioceramic composites, and the control animals were implanted with single-tube porous β-TCP bioceramic scaffolds. At 12 weeks' postoperatively, the osteogenic effects between two groups were compared by local X-ray film, local bone appearance, histology, osteogenic area per field, and compression strength measured after sacrifice. Results: At 12 weeks after surgery, X-ray, bone appearance, histological staining, and osteogenic area per field showed that the scores in the observation group were significantly better than the control group (P < 0.05). Furthermore, the compression strength of the regenerated bone in the observation group was significantly higher than that of the control group (P < 0.05). Conclusion: The double-tube PCL/β-TCP bioceramic composite has promising therapeutic effects, osteogenic effect and mechanical properties in the treatment of bone defects, and thus may be of clinical significance.
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REVIEW ARTICLE Top

Progress of diagnosis and surgical treatment in children with moyamoya disease p. 83
Hongbo Zhang, Mengmeng Bai, Zhiqi Chen, Zhengliang Li, Shizhong Zhang, Wen Li
DOI:10.4103/ts.ts_17_18  
Moyamoya disease (MMD), also known as abnormal intracranial vascular network, is a group of chronic progressive stenosis or occlusion of bilateral main branches of Willis ring (siphon segment of internal carotid artery and anterior and middle cerebral arteries, sometimes including the origin of posterior cerebral artery), followed by abnormal collateral small vascular network. The disease is known as MMD because it presents many dense piles of small blood vessels that appear as “puff of smoke” on cerebral angiogram. At present, great progress has been made in the field of epidemiology, pathogenesis, clinical manifestations, diagnosis, and treatment of adult MMD. However, the disease characteristics considerably differ in children. Therefore, this article will review the diagnosis, treatment, and prognosis of MMD in children.
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