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Year : 2018  |  Volume : 3  |  Issue : 4  |  Page : 79-82

The efficacy of double-tube polycaprolactone/β-tricalcium phosphate bioceramic composite in the treatment of bone defects

Department of Orthopaedics, Eastern Theater General Hospital, Nanjing, Jiangsu, China

Correspondence Address:
Dr. Xing Zhou
Department of Orthopaedics, Eastern Theater General Hospital, Nanjing 210002, Jiangsu
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ts.ts_16_18

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Aim: The study aims to investigate the efficacy of double-tube polycaprolactone (PCL)/β-tricalcium phosphate (β-TCP) bioceramic composites in the treatment of bone defects. Methods: Forty healthy female New Zealand white rabbits, aged 6–10 months and weighing about 3 kg, were randomly divided into observation group (n = 20) and control group (n = 20) according to the random number table. The animals in the observation group were implanted with double-tube PCL/β-TCP bioceramic composites, and the control animals were implanted with single-tube porous β-TCP bioceramic scaffolds. At 12 weeks' postoperatively, the osteogenic effects between two groups were compared by local X-ray film, local bone appearance, histology, osteogenic area per field, and compression strength measured after sacrifice. Results: At 12 weeks after surgery, X-ray, bone appearance, histological staining, and osteogenic area per field showed that the scores in the observation group were significantly better than the control group (P < 0.05). Furthermore, the compression strength of the regenerated bone in the observation group was significantly higher than that of the control group (P < 0.05). Conclusion: The double-tube PCL/β-TCP bioceramic composite has promising therapeutic effects, osteogenic effect and mechanical properties in the treatment of bone defects, and thus may be of clinical significance.

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