• Users Online: 353
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2018  |  Volume : 3  |  Issue : 4  |  Page : 69-74

Rapid increase in serum iron level after oral iron intake as an indicator of duodenal iron absorption and inverse regulation of iron absorption by hepcidin expression


1 Department of Orthopaedic Surgery, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
2 Department of Advanced Medicine, Kanazawa Medical University Graduate School of Medical Science, Uchinada, Ishikawa, Japan

Correspondence Address:
Dr. Xipeng Wang
Department of Orthopaedic Surgery, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430077, Hubei
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ts.ts_15_18

Rights and Permissions

Aim: Hepcidin is a hepatocyte-derived peptide that is thought to be involved in the regulation of intestinal iron absorption. Ferric citrate (FC) is a phosphate binder with additional effects on iron absorption. Better understanding of iron absorption under various levels of hepcidin may improve FC supplementation in individuals with renal anemia. We provide a new method to predict the individual iron absorption ability of the duodenum. Methods: Rats on an ordinary diet were given 10 mg of FC, and the serum concentrations of hepcidin and iron were monitored for 24 h. Rats with hepcidin levels induced by using alternative methods such as bloodletting or intravenous iron loading were also given FC, and serum iron level was measured at 2 h after oral iron intake (2-h oral iron absorption test). Results: Serum iron level increased constantly within 2 h after oral iron intake, and serum hepcidin level peaked 4 h after the iron level peaked. In the oral iron absorption test, the hepcidin levels inversely correlated with increased serum iron levels and hepcidin expression levels of >80 ng/mL completely inhibited the increase in iron absorption. Conclusion: This study suggests that hepcidin expression may be a strong mediator to regulate iron absorption and that performing an oral iron absorption test with hepcidin may help improve oral iron dosing schedules in patients undergoing hemodialysis.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed330    
    Printed57    
    Emailed0    
    PDF Downloaded73    
    Comments [Add]    

Recommend this journal