• Users Online: 201
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2018  |  Volume : 3  |  Issue : 2  |  Page : 23-27

Role of Angiopoietin-2 in the control of malignant pleural effusion and survival in patients with primary lung adenocarcinoma


Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

Correspondence Address:
Dr. Wenkui Sun
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ts.ts_25_17

Rights and Permissions

Aim: This study aimed to investigate the role of angiopoietin-2 (Ang-2) in the local control of malignant pleural effusion (MPE) and survival in patients with primary lung adenocarcinoma. Methods: Pleural effusion and blood samples were obtained from 85 patients with lung adenocarcinoma and MPE. Enzyme-linked immunosorbent assay was performed to investigate the expression levels of Ang-2 in pleural effusions and serums. SPSS software (Version 18.0) was used to analyze the data. Results: We found that the expression levels of Ang-2 in pleural effusion and serum were 26.82 ± 8.82 pg/mL and 358.78 ± 95.93 pg/mL, respectively. The expression level of Ang-2 in pleural effusion was found to be correlated with the control of pleural effusion. Based on receiver operating characteristic curve analysis, we found that when the cutoff value was 25.57 pg/mL, the efficacy of pleural effusion Ang-2 level in evaluating the control of pleural effusion could get the best result. Both the pleural effusion Ang-2 level and the local control of pleural effusion are independent factors affecting the prognosis of patients with lung cancer and MPE. However, this study also found that serum Ang-2 levels had no significant correlation with MPE local control or prognosis. Conclusion: Pleural effusion Ang-2 levels can be used as a molecular biomarker to predict both the MPE local control and prognosis of the MPE patients, which has significant clinical value.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed254    
    Printed27    
    Emailed0    
    PDF Downloaded69    
    Comments [Add]    

Recommend this journal