• Users Online: 44
  • Home
  • Print this page
  • Email this page
Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2016  |  Volume : 1  |  Issue : 2  |  Page : 37-40

The overexpression of leucine-rich repeat-containing g-protein-coupled receptor 5 in pituitary adenomas


1 Department of Neurosurgery, Binzhou People's Hospital, Binzhou, Shandong, China
2 Department of Anesthesiology, Binzhou People's Hospital, Binzhou, Shandong, China
3 Department of Orthopedic Surgery, Tongan Hospital of Dongying, Shandong, China

Correspondence Address:
Jiuzhou Li
Department of Neurosurgery, Binzhou People's Hospital, Binzhou, Shandong 256600
China
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2468-5585.185197

Rights and Permissions

Aim: To determine the leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) level in human pituitary adenomas and the role of LGR5 in the development of human pituitary adenomas. Methods: Immunohistochemistry is performed to determine the expression of LGR5 in pituitary adenomas and normal pituitaries. LGR5 expression level is determined by the criteria as follows. The one-way analysis of variance (ANOVA) was used to evaluate any significant differences of LGR5 among individual groups. The correlation between expression and the other clinical factors were evaluated by using the Mann-Whitney test and one-way ANOVA. Results: LGR5 is significantly overexpressed in pituitary adenomas compared to normal pituitaries. Conclusion: The overexpression of LGR5 may facilitate the growth of these tumors. Potentially, the finding in the study could be exploited to develop innovative molecular targeted diagnosis and treatment for human pituitary adenomas.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed2026    
    Printed213    
    Emailed0    
    PDF Downloaded249    
    Comments [Add]    
    Cited by others 1    

Recommend this journal