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ORIGINAL ARTICLE
Year : 2016  |  Volume : 1  |  Issue : 2  |  Page : 33-36

Clinical research on the therapeutic effects of the combination of rociverine and suoquan in the treatment of female patients with overactive bladder


Department of Urological Surgery, The Second People's Hospital of Lianyungang, Lianyungang, Jiangsu, China

Correspondence Address:
Dongwei Yao
Department of Urological Surgery, The Second People's Hospital of Lianyungang, No. 41, Hailian East Road, Lianyungang 222000, Jiangsu
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2468-5585.185196

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Aim: The aim of this study is to explore the efficacy and safety of combination of rociverine with suoquan in the treatment of female patients with overactive bladder (OAB). Methods: A total of 142 cases of female patients with OAB were accepted outpatient treatment from October 2011 to October 2014, and randomly divided into 3 groups. A total of 53 patients were assigned to the oral rociverine alone group with 10 mg tablets, 3 times per day; 48 patients were assigned to the oral suoquan capsule alone group, with 1.8 g, 3 times per day; and 51 patients were assigned to the oral combination group, with 10 mg rociverine and 1.8 g suoquan, 3 times per day. The treatment duration for all groups was 4 weeks. Three-day voiding diaries were recorded for all patients before selection and after a 4-week course of therapy. The number of micturition events, urgent voiding events, incontinence events, nocturia events in a 24 h period was recorded. In addition, the changes in voided volume, subjective indicator OAB symptom scores (OABSS), and adverse reactions were recorded for efficacy and safety evaluation. Results: The total number of urination events, urgent voiding events, incontinence events, and nocturnal voiding events within a 24 h period between treatment groups was significant. In addition, the volume of voided urine and OABSS was significantly different between groups (P < 0.05). When comparing the therapeutic effects of the combination group to the single drug rociverine and suoquan groups, the difference was statistically significant (P < 0.05). The comparative difference between rociverine alone and suoquan alone groups was not statistically significant (P > 0.05). The drug adverse reaction rate of the combination group (7.8%) was less than that of rociverine alone group (22.6%). The comparative difference between the 2 groups was statistically significant (P = 0.032). Conclusion: The combination of rociverine and suoquan for the treatment of female patients with OAB has a favorable therapeutic effect and a good safety profile.


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